Zero/Sum

"Zero/Sum is a cinematic puzzle game that combines unique puzzle gameplay with a ridiculous action movie storyline- complete with live action cutscenes!"

"On the eve of discovering a mathematical cure for cancer, your mentor, Professor Claire Liddy, is murdered. Fortunately, before she died, the Professor was able to erase many of the plus and minus signs with her bloody hands, saving the cure from falling into the hands of her killers. Now it is up to you to fill back in the missing parts of the equation and resolve your professor's cure. It's up to you to cure cancer -- AGAIN! (It's a comedy)."